Xanthogranulomatous Pyelonephritis

Rare form of chronic pyelonephritis and represents a chronic granulomatous disease resulting in a non-functioning kidney

Aetiology

  • Chronic granulomatous process believed to be the result of subacute/chronic infection inciting a chronic but incomplete immune reaction

Pathophysiology

  • Inflammatory but has all radiological features of malignancy

Clinical presentation

  • Typically vague, consisting of constitutional symptoms such as malaise, weight loss and low-grade fever
  • Haematuria and flank pain are sometimes encountered

Investigations

  • Imaging - x-ray, USS, CT (most useful), MRI

Management

  • Surgical nephrectomy is usually curative