Autonomic Pharmacology I

Functions of the ANS

  • Mediates output from the whole body except skeletal muscle
    • Output modulated by external and internal sensory input, often via reflexes
      • Reflexes: negative feedback loops within PNS and CNS
  • Regulates functions essential to human health and life that do not require conscious effort e.g. contraction and relaxation of vascular and visceral smooth muscle, heartbeat, metabolism, immune system
  • Training allows some conscious influence over some ANS reflexes

Basic organisation of the motor ANS

  • Regulates essential physiological functions, helping to maintain homeostasis via complementary actions of the sympathetic and parasympathetic divisions

Sympathetic ANS

  • ‘Fight or flight’
  • Preganglionic neurones originate in the thoracolumbar region

Parasympathetic ANS

  • ‘Rest and digest’
  • Preganglionic neurons originate in the craniosacral region

Chemical transmission in the ANS

Sympathetic division

  • Transmitter for preganglionic neurons - acetylcholine (ACh)
  • Transmitter for postganglionic neurons - noradrenaline (NA)

Parasympathetic division

  • Transmitter for preganglionic neurons - acetylcholine (ACh)
  • Transmitter for postganglionic neurons - acetylcholine (ACh)

Other transmitters

  • NANC transmission - does not use ACh or NA
  • More often, ACh/NA is co-released with a NANC co-transmitter
    • Sympathetic - ATP and NPY
    • Parasympathetic - NO and VIP
    • Different response times