Inflammatory and infectious condition of the lacrimal sac, most commonly resulting from obstruction of the nasolacrimal duct
Aetiology
Primary Etiology
- Nasolacrimal duct obstruction (NLDO)
- Idiopathic (most common in adults)
- Congenital (in infants)
- Inflammatory stenosis
- Age-related involutional changes
Secondary Causes
- Chronic rhinosinusitis
- Nasal trauma or surgery
- Nasal or sinus tumors
- Facial fractures
- Iatrogenic causes (e.g., radiotherapy)
Microbiological Agents
- Acute dacryocystitis
- Staphylococcus aureus
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Haemophilus influenzae
- Chronic dacryocystitis
- Staphylococcus epidermidis
- Gram-negative bacilli
- Anaerobic organisms
Clinical presentation
Acute Dacryocystitis
Symptoms
- Sudden onset pain and swelling over the medial canthus
- Redness and warmth of overlying skin
- Epiphora
- Fever and malaise (in severe cases)
Signs
- Tender, erythematous swelling over the lacrimal sac
- Fluctuance if abscess has formed
- Purulent discharge expressed from puncta on pressure (regurgitation test positive)

Chronic Dacryocystitis
Symptoms
- Chronic epiphora
- Recurrent conjunctivitis
- Intermittent mucopurulent discharge
Signs
- Non-tender swelling or fullness over the lacrimal sac
- Regurgitation of mucopurulent material on pressure
- Minimal skin inflammation
Investigations
Clinical Evaluation
- Detailed history (onset, systemic symptoms, recurrence)
- Complete ophthalmic examination including visual acuity and ocular motility
- Anel Test negative
Laboratory Studies
- Complete blood count (CBC)
- Inflammatory markers (ESR, CRP)
- Viral serology (e.g., EBV) when indicated
- Autoimmune markers (ANA, ANCA, serum IgG4) in chronic or bilateral cases
Imaging
CT or MRI of the orbit to assess gland enlargement, abscess formation, or orbital involvement
Biopsy
- Indicated in:
- Chronic or recurrent dacryoadenitis
- Atypical presentations
- Suspected neoplastic or IgG4-related disease
Management
Acute Dacryocystitis
- Systemic broad-spectrum antibiotics (covering Gram-positive and Gram-negative organisms)
- Analgesics and anti-inflammatory agents
- Warm compresses
- Incision and drainage if abscess formation is present (avoid syringing during acute infection)
Chronic Dacryocystitis
- Definitive management with dacryocystorhinostomy (DCR):
- External or endoscopic approach
- Topical antibiotics for associated conjunctivitis
- Management of underlying nasal pathology if present