Irritable Bowel Syndrome (IBS)

Refers to a group of symptoms, including abdominal pain and discomfort, bloating, and change in bowel habit, for which no underlying cause or pathology can be identified

Aetiology

  • Onset generally <45 but persists into old age

Risk factors

  • Female gender (2:1)
  • Family history
  • Mental health problem e.g. anxiety

Clinical presentation

Symptoms

  • Abdominal pain often relieved by defaecation
  • Misbehaving bowels - constipation (IBS-C), diarrhoea (IBS-D) or mixed (IBS-M)

Signs

  • May be tenderness in left iliac fossa

Investigations

  • Diagnosis is symptom based

Rome III diagnostic criteria

  • Recurrent abdominal pain or discomfort at least 3 days per month in the last 3 months associated with 2 or more of the following:
    • Improvement with defaecation
    • Onset associated with change in frequency of stool
    • Onset associated with a change in the form of stool

Bloods

  • Used to rule out other causes, should be normal
  • FBC, coeliac serology, CRP, TSH

AXR

  • Consider selectively

Management

Dietary advice (first line)

  • ‘If it upsets you, don’t eat it’
  • Increase fibre in IBS-C, decrease fibre in IBS-D

Low FODMAP diet (second line)

  • Group of short-chain carbohydrates poorly digested in small intestines leading to fermentation and osmotic changes in large bowel
  • Eliminate all FODMAP for 2-6 weeks, then reintroduce gradually to identify triggers

Pharmacological treatment

  • IBS-D - anti-diarrhoeals (loperamide)
  • IBS-C - osmotic laxatives (avoid stimulant laxatives)
  • Patients may be given 4-week trial of probiotics