Associated Conditions and Other Types of DM

Cystic fibrosis

  • Increasing prevalence as patients with CF live longer
  • >25% of CF patients have CFRD at 20 years
  • Usually found in 'severe' mutations i.e. 𝝙508
  • Prone to complications
  • Insulin therapy preferrent
  • Screening with OGTT from age 10 recommended

DIDMOAD or Wolfram syndrome

  • Genetic condition characterized by diabetes insipidus (DI), childhood-onset diabetes mellitus (DM), a gradual loss of vision caused by optic atrophy (OA), and deafness (D)

Barget-Biedl syndrome

  • Genetic condition that impacts multiple body systems
  • The cardinal features of BBS are truncal obesity, intellectual impairment, renal anomalies, polydactyly, retinal degeneration and hypogenitalism
  • T2DM has been estimated to affect up to 45% of patients with BBS
  • Associated with consanguineous parents

Autoimmune conditions associated with T1DM

Relatively common

  • Thyroid disease
  • Coeliac disease
  • Pernicious anaemia
  • Addison's disease
  • IgA deficiency

Rare/very rare

  • Autoimmune polyglandular syndromes
  • AIRE mutations
  • IPEX syndrome